I have a popup "Cannot Start Application"

When starting scanning, i got the following popup:

Clicking on details can result into many possibilities.

Possible solutions are:

1) ERROR DETAILS

Following errors were detected during this operation.
 * [8/11/2013 14:04:59] System.Deployment.Application.InvalidDeploymentException (Manifest)
  - Your Web browser settings do not allow you to run signed applications.
  - Source: System.Deployment
  - Stack trace:  
      at System.Deployment.Application.ApplicationActivator.BrowserSettings.Validate(String manifestPath)
      at System.Deployment.Application.ApplicationActivator.PerformDeploymentActivation(Uri activationUri, Boolean isShortcut, String textualSubId, String deploymentProviderUrlFromExtension, BrowserSettings browserSettings, String& errorPageUrl)
      at System.Deployment.Application.ApplicationActivator.ActivateDeploymentWorker(Object state)

Solution

The security settings of your browser doesn't allow you to start a .NET component that was signed with a certificate.
This setting can be found via Internet Options > Security > Zone > Custom level …